Genetic model misspecification in genetic association studies
نویسندگان
چکیده
منابع مشابه
Expanded publishing model for genetic association studies.
To the Editors: While stressing the need to integrate epidemiology and biology for causal inference, new CEBP publication criteria will exclude the results of many genetic association studies (1). Clearly, editors must prioritize because journal pages are limited; at the same time, epidemiologists are able to measure thousands of genetic variants and potentially millions of gene-gene and gene-e...
متن کاملGenetic association studies.
To the Editor: I am delighted to see that Arteriosclerosis, Thrombosis, and Vascular Biology has taken the lead in initiating an open discussion about genetic association studies in such a prominent manner. As correctly pointed out in the editorial by Dr Hegele,1 the number of publications has exponentially increased in the last decade. Despite the intrinsic problems with this approach, this ex...
متن کاملGenetic association studies.
With the completion of the HapMap project1 and the development of technology that allows the examination of 1 million genetic polymorphisms at once, genetic association studies are becoming more comprehensive. This article first provides a brief overview of the rationale for genetic association studies; it then discusses the primary features differentiating genetic from standard association stu...
متن کاملGenetic association studies.
The widespread availability of DNA from large population studies, the development of rapid throughput genotyping assays, and the identification of numerous polymorphisms in genes of interest make it easier to perform genetic association studies in humans. We consider these studies appropriate areas of research in relation to atherosclerosis, thrombosis, and vascular biology. In this issue, Drs ...
متن کاملGenetic Association Studies in Stroke
Background and Purpose—A large number of candidate gene association studies have attempted to identify genes implicated in stroke, but there have been few replicable and robust associations reported. Summary of Review—The skantness of replicable associations partly relates to poor study design. Important methodological considerations include adequate sample size, the selection of appropriate co...
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ژورنال
عنوان ژورنال: BMC Research Notes
سال: 2017
ISSN: 1756-0500
DOI: 10.1186/s13104-017-2911-3